Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata.

doi:10.1139/cjpp-2016-0407

Paper

Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata.

Published May 1, 2017 · Rong Dai, Ting Wang, Xiaoqin Si

Canadian journal of physiology and pharmacology

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18

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Abstract

The objective of this study was to assess the ethyl acetate extracts of Gastrodia elata Blume (GEB) on vascular tone and the mechanisms involved. GEB was extracted with 95% EtOH followed by a further extraction with ethyl acetate. The effects of GEB and its ingredients on the isometric tensions of the aortic rings from rats were measured. The ethyl acetate extract of GEB induced a vasodilatory effect on rat aorta, which was partially dependent on endothelium. Four chemical compounds isolated from GEB were identified as 3,4-dihydroxybenzaldehyde (DB), 4-hydroxybenzaldehyde (HB), 4-methoxybenzyl alcohol (MA), and 4,4'-dihydroxydiphenyl methane (DM), respectively. All of these compounds induced vasodilatations, which were dependent on the endothelium to different degrees. After pretreatment with Nω-nitro-l-arginine methyl ester, indomethacin, or methylene blue, the vasodilatations induced by DB, HB, and MA were significantly decreased. In addition, the contractions of the rat aortic rings due to Ca2+ influx and intracellular Ca2+ release were also inhibited by DM. Furthermore, the administration of DB significantly enhanced the productions of nitric oxide (NO) and the activities of the endothelial NO synthase in aorta and in endothelial cells. Thus, GEB may play an important role in the amelioration of hypertension by modulating vascular tones.

Non-RCT

Animal Study

Study Snapshot

Gastrodia elata Blume (GEB) ethyl acetate extracts may help reduce hypertension by modulating vascular tones, with potential benefits from nitric oxide production and endothelial NO synthase activation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata.

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References

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Citations

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