Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism

doi:10.1016/S0028-3908(99)00052-0

Paper

DOI: 10.1016/S0028-3908(99)00052-0

Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism

Published Aug 1, 1999 · L. Dawson, H. Nguyen, A. Geiger

Neuropharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

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Study Snapshot

Venlafaxine increases noradrenaline in the rat frontal cortex, with its effects enhanced by 5-HT1A receptor antagonism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.3389/fphar.2017.00995

Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles

Bupleuri Radix has a milder toxic reaction in healthy rats than in chronic unpredictable mild stress rats, suggesting a more rational and safer application of clinical drugs in the future.

2018·34citations·Xiaoxia Gao et al.·Frontiers in Pharmacology

Frontiers in Pharmacology

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Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats

Agomelatine, venlafaxine, and voluntary wheel running effectively prevent anxiety- and depression-like behaviors and memory impairment in stressed rats.

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PLoS ONE

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Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD

Levo-stepholidine (l-SPD) exhibits antidepressant-like effects in rats by selectively activating D1R receptors in the medial prefrontal cortex, enhancing synaptogenesis and long-term synaptic potentiation.

2017·23citations·Bing Zhang et al.·Scientific Reports

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Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release?

Antidepressants with increased serotonin levels may cause sexual side effects, while those with increased dopamine and noradrenaline levels do not, suggesting that novel treatments should focus on increasing both serotonin and dopamine signaling.

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Pharmacology Biochemistry and Behavior

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Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum.

Acute and chronic venlafaxine and desipramine administration maximally activate prefrontal adrenergic and dopaminergic systems without affecting striatal dopaminergic systems in mice.

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