Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment.

Paper

Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment.

Published Sep 1, 2011 · T. Pavicic, G. Gauglitz, P. Lersch

Journal of drugs in dermatology : JDD

Q2 SJR score

126

Citations

5

Influential Citations

Semantic Scholar

Abstract

BACKGROUND Due to its strong water-binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. Native HA is proposed to help the skin to retain and maintain elasticity, turgor and moisture. OBJECTIVE To observe the efficacy of topical application of 0.1% hyaluronan formulations of different molecular weights (MW) (50, 130, 300, 800 and 2000 kDa, respectively) in the periocular area as anti-wrinkle treatment. MATERIAL AND METHODS Seventy-six female subjects between 30 and 60 years of age with clinical signs of periocular wrinkles applied one of the formulations twice-daily to the area of interest in a randomized fashion for 60 days. Around the other eye, a vehicle control cream was applied. Measurements of skin hydration and skin elasticity were performed before treatment, 30 and 60 days thereafter. At similar time points negative replicas were taken and evaluated by semi-automated morphometry. RESULTS All HA-based creams utilized in this study demonstrated a significant improvement in skin hydration and overall elasticity values (R2) when compared to placebo. Measurements of wrinkle depth using mean roughness (Ra) and maximum roughness (Rz) values revealed significant improvement in the 130 and the 50 kDa HA group after 60 days of treatment compared to placebo-treated area. CONCLUSION Topical application of all 0.1% HA formulations used in this study led to significant improvement in skin hydration and elasticity. Application of low-molecular-weight (LMW) HA was associated with significant reduction of wrinkle depth, which may be due to better penetration abilities of LMW HA.

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Study Snapshot

Topical application of 0.1% hyaluronic acid formulations improves skin hydration and elasticity, with low-molecular-weight hyaluronic acid significantly reducing wrinkle depth.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment.

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References

Citations

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Hyaluronic acid-solid lipid nanoparticles effectively enhance topical tretinoin delivery, improving skin conditions and reducing wrinkles in 90% of tested individuals after 4 weeks of treatment.

In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing

The eye cream effectively reduced all periorbital ageing signs, including wrinkles, eyelid sagging, and dark circles, with its effects supported by in vitro and ex vivo analyses of molecular markers.

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