N. M. Sekhar, P. Acharyulu, Y. Anjaneyulu
Aug 10, 2011
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3- d ]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.