S. Elz, W. Schunack
Feb 1, 1987
Citations
0
Influential Citations
10
Citations
Journal
Zeitschrift für Naturforschung B
Abstract
Abstract Bromination of N-(4-oxopentyl)phthalimide (3) leads to isomeric bromoketones 2a and 2e, which undergo cyclisation with formamidine in liquid ammonia to yield homohistamine (1a) and 5-methylhistamine (1e). Similarly racemic a-methyl-(1b) and 2-methylhomohistamine (1c) are synthesized. The resolution of 1b is achieved using (+)-and (-)-di-0-(4-toluoyl)tartaric acid. 1 are intermediates in the synthesis of impromidine like, H2 -histaminergic compounds.