Paper
Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants.
Published Jun 1, 2018 · D. Marciani
Trends in pharmacological sciences
Q1 SJR score
79
Citations
6
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Saponin-derived adjuvants can induce either proinflammatory Th1/Th2 or sole anti-inflammatory Th2 immunity, with different structures and oligosaccharides affecting dendritic cell activation.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
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Nature Communications
Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide.
QS-21-based vaccine adjuvants with a terminal-functionalized side chain in the West Wing Trisaccharide show potential for developing new saponin-based vaccine adjuvants with comparable activity to GPI-0100.
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Citations
Levamisole, as a viral vaccine adjuvant, induces robust host defense through the modulation of innate and adaptive immune responses
Levamisole, as an adjuvant for foot-and-mouth disease vaccines, can enhance host defense against viral infections by modulating innate and adaptive immune responses.
2025·0citations·Gang Sik Kim et al.·Frontiers in Microbiology
Frontiers in Microbiology
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Saponins from Quillaja saponaria bark and Quillaja brasiliensis leaves are used as vaccine adjuvants, with various preparations and purification methods for each saponin.
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Frontiers in Natural Products
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Viral immunology
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Frontiers in Drug Delivery