Anders Korhonen, K. Hemminki, H. Vainio
Apr 1, 1983
Citations
0
Influential Citations
18
Citations
Quality indicators
Journal
Journal of Applied Toxicology
Abstract
Sixteen amine compounds that are used in the rubber industry, and sodium nitrite, were tested on three‐day chicken embryos for embryotoxicity. The parameters measured were: early deaths recorded within two days of injection, late deaths of malformed embryos, late deaths of non‐malformed embryos and malformed survivors. The most embryotoxic chemicals were N‐phenyl‐N′‐isopropyl‐p‐phenylenediamine, N,N,N,‐triethylethylenediamine, N,N′,‐dicyclohexyl‐p‐phenyleneamine and triethylamine, with total effect ED50 values, including deaths and malformations, between 0.11 and 0.90 μmol per egg. The ED50 values for triethylenetetramine, N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine, triethanolamine, N‐phenyl‐2‐naphtylamine, aniline and N‐nitrosodiphenylamine ranged from 1.1 to 7.0 μnol per egg. Sodium nitrite was the least potent, with an ED50 of 22 μmol per egg. Six chemicals produced no effects. They probably did not reach the embryo. The four most potent chemicals, together with aniline, caused the highest frequencies of malformations.