Qi Peng, Fu-jie Chen, Zhenlin Zhong
Aug 3, 2010
Citations
1
Influential Citations
83
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Quality indicators
Journal
Chemical communications
Abstract
Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.