Guo Hai
2007
Citations
0
Influential Citations
2
Citations
Journal
Chemical Intermediates
Abstract
2-Thiophenecarboxylic acid was synthesized from thiophene through bromination with pyridine hydrobromide perbromide to give 2-bromothiophene,followed by Grignard reaction in MeTHF as a solvent,then reacted with triethyl orthoformate and hydrolyzed to give 2-thiophenecarboxaldehyde,finally oxided with H2O2.The synthesis technique was environmental-friendly with an overall yield of 74%.