K. Naemura, A. Furutani
1990
Citations
0
Influential Citations
4
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
2,6-Bis(acetoxymethyl)-2,6-bis(hydroxymethyl)spiro[3.3]heptane with axial chirality and moderate optical purity has been prepared in high chemical yield by pig liver esterase-catalysed asymmetric hydrolysis of 2,2,6,6-tetrakis (acetoxymethyl)spiro[3.3]heptane. Similarly, racemic 2,6-disubstituted spiro[3.3] heptane derivatives with axial chirality were resolved by enantioselective enzyme-catalysed hydrolysis.