L. Mazur, P. Borowicz, Urszula Kłaput
2015
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Journal
Acta Biologica Cracoviensia. Series Botanica. Supplement
Abstract
(-)-Epigallocatechin-3-gallate (EGCG) represents natural polyphenolic compounds of the plant origin. Epirubicin (EPI) belongs to the second generation of anthracycline drugs. The present study was undertaken to assess a possible influence of EGCG and/or EPI on human histiocytic lymphoma U937 cells. The in vitro research was conducted using the Beckman Coulter method of cell sizing, as well as flow cytometry – FSC/SSC (forward scatter/side scatter) and FDA/PI (fluorescein diacetate/ propidium iodide) assays. The morphological and functional changes caused in U937 cells by each tested agent, EGCG and MAF, given alone or in combinations, were determined. The cytotoxic effects of (-)-epigallocatechin-3-gallate and epirubicin on human histiocytic lymphoma cells were shown. The combinations with EGCG enhanced the cytotoxic activity of epirubicin against U937 cells.