L. Tietze, H. Geissler
Apr 15, 2001
Citations
0
Influential Citations
0
Citations
Journal
Journal name not available for this finding
Abstract
[10601-80-6] C9H18O4 (MW 190.27) InChI = 1S/C9H18O4/c1-4-11-8(10)7-9(12-5-2)13-6-3/h9H,4-7H2,1-3H3 InChIKey = SIALOQYKFQEKOG-UHFFFAOYSA-N (synthesis of heterocycles; Pictet–Spengler reaction;1 malonaldehyde monoacetal;2 enantiomeric pure γ-amino-β-hydroxybutanoic acid3) Alternate Name: ethyl 3,3-diethoxypropionate. Physical Data: bp 92–95 °C/15 mmHg; d 0.978 g cm−3. Solubility: sol water, diethyl ether. Form Supplied in: colorless liquid; widely available. Analysis of Reagent Purity: n20D = 1.4117. Preparative Methods: can be obtained by treatment of 1,1,1-trichloro-4-ethoxy-3-buten-2-one with ethanol in the presence of catalytic amounts of Potassium Carbonate. The trichloromethyl ketone is prepared from Ethyl Vinyl Ether and Trichloroacetyl Chloride.4 Purification: fractional vacuum distillation through a short Vigreux column. Handling, Storage, and Precautions: ethyl 3,3-diethoxypropanoate is the stable, protected derivative of the unstable 3-oxopropanoate. It can be stored at room temperature for several months without decomposition.