B. Cattanach, C. E. Pollard, J. Isaacson
Sep 1, 1968
Citations
0
Influential Citations
110
Citations
Quality indicators
Journal
Mutation research
Abstract
Abstract Ethyl methanesulfonate (EMS) induced high frequencies of dominant lethal mutations in mouse epididymal spermatozoa and late spermatids and lower frequencies in vas deferens spermatozoa and early spermatids. Pre-meiotic germ cell stages were relatively resistent to the induction of dominant lethals and cell killing. The same dose of the chemical also induced high frequencies of translocations among the F 1 offspring, the frequencies being highest among offspring from the germ cell stages most sensitive to the induction of dominant lethals. Evidence is presented which support the concept that F 1 male sterility, like F 1 male semi-sterility, has a basis of chromosome breakage.