J. Buckley, S. Shanor, J. Gloss
1964
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The hypotensive activity of a series of 2,2,6,6-tetramethylpiperidine derivatives was investigated in anesthetized rats and dogs. The piperidine compounds were derivatives of pempidine (1,2,2,6,6-pentamethylpiperidine), an orally effective potent ganglionic blocking compound. N -Amino- N -[ β -(2,2,6,6-tetramethylpiperidino-)-ethyl]-guanidine sulfate (EX 4510) appeared to be slightly more active than pempidine. All of the active hypotensive compounds in this series which were tested against pressor challengers in anesthetized dogs potentiated the epinephrine and angiotensin II pressor responses and depressed or blocked the bilateral carotid occlusion pressor response. Preliminary data suggest that the active compounds, like pempidine, are ganglionic blockers.