Evolution and Exploration of Azadirachta indica in Dentistry: An Update

doi:10.9734/bjmmr/2017/33538

Paper

Evolution and Exploration of Azadirachta indica in Dentistry: An Update

Published Jan 10, 2017 · Abhaya R. Gupta, U. Verma, N. Lal

British journal of medicine and medical research

UNKNOWN SJR score

7

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1

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Abstract

Despite great achievements globally in oral health of populations, dental caries and periodontal diseases are the most important oral health burdens particularly among under-privileged groups in developed and developing countries. Nonetheless, oral cancer is the sixth most common cancer reported globally with an annual incidence of over 300,000 cases, of which 62% arise in developing countries. Apart from the traditional therapeutic modalities available so far that are usually synthetic drugs, researchers are presently discovering unexplored horizons of herbs for curing these ailments. One such beneficial herb is Azadirachta indica (Neem) that has been widely accepted throughout the world for its innumerable medicinal properties. The limitless benefits of neem has been documented in Indian traditional medicinal books like ‘Charak – Samhita’ & ‘Sushruta – Samhita’. Neem tree has been valued long back, since centuries by the Indian citizens for cleaning the teeth, skin diseases, consumption as a tonic & eradicating worms etc & many more. The present review discusses the in-vivo, in-vitro and animal studies utilizing the electronic Review Article databases Pubmed, Embase and Google Scholar till 31 st December 2016 that highlights the medicinal properties of this wonder herb from oral health point of view suggesting its role as antigingivitis, anti-microbial, antiplaque, anticandidiasis, anti-periodontitis, effective endodontic irrigant, dental erosion therapy, anticaries & oral cancer therapy. Although the results are encouraging, but more scientific validation is required so that the incorporation of this ayurvedic herb into modern dentistry could be justified.

Systematic Review

Very Rigorous Journal

Study Snapshot

Key takeawayNeem, or Azadirachta indica, shows potential in treating oral health issues like gingivitis, periodontal diseases, and oral cancer.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Evolution and Exploration of Azadirachta indica in Dentistry: An Update

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References

Effectiveness of Azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review

Neem mouthrinses show promise in reducing plaque and gingival inflammation when used as an adjunct to toothbrushing, but more high-quality randomized controlled trials are needed to confirm their clinical use.

Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial.

Neem-containing toothpaste can effectively reduce plaque and gingivitis, improving oral hygiene and overall health.

Antibacterial efficacy of Azadirachta indica, Mimusops elengi and 2% CHX on multispecies dentinal biofilm

Methanolic extracts of Azadirachta indica, Mimusops elengi, and 2% Chlorhexidine gluconate show considerable antimicrobial activity against polymicrobial dentinal biofilm of common endodontic pathogens.

Ultra structural study of the rat cheek epithelium treated with Neem extract.

Neem extract shows differences in the ultrastructure of rat oral epithelium, but these structural differences may not be related to adverse side effects.

Effect of Two Herbal Mouthwashes on Gingival Health of School Children

Chlorhexidine and neem mouthwashes effectively reduce plaque, while chlorhexidine has superior antigingivitis properties in school children aged 12-15 years.

Citations

Potential Role of Medicinal Plants and their Phytochemicals against Plaque forming Oral Microbiota

Medicinal plants, such as Ocimum basilicum, Azadirachta indica, Syzygium aromaticum, Acacia nilotica, and Achyranthes aspera, contain bioactive compounds that effectively prevent dental plaque formation and are safer than chemical agents.

Azadirachta Indiaca (Neem) Leaf

Neem is a fast-growing tree native to India and Burma, with each part of the tree having medicinal properties.

Azadirachta indica –Neem-A natural gift for prevention and treatment of chronic diseases- A review

Neem plant, containing over 300 phytochemicals, is a significant medicinal herb used for prevention and treatment of various chronic diseases in various medical systems.

A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films

Electrospun buccal films show better swelling and mucoadhesive properties, better drug release, and higher antibacterial activity compared to solvent cast films for oral therapeutic applications.

Qualitative and Quantitative Ethnobotanical Analysis of Ricinus communis L. and Azadirachta indica A. Juss. in Sonipat District of Haryana, India

Ricinus communis seeds are used to treat arthritis and Azadirachta indica leaves are used for skin disease treatment in Sonipat District, Haryana, India.

Comparative Study of the Phytochemical and Bio-activities of the Essential Oils from Ripe and Unripe Seeds of Azadirachta indica

Essential oils from both ripe and unripe Azadirachta indica seeds show high antimicrobial strength, with unripe seeds having higher antimicrobial strength.