K. Ertel, J. Carstensen
Mar 1, 1988
Citations
4
Influential Citations
52
Citations
Journal
International Journal of Pharmaceutics
Abstract
Abstract The effect of various preparation conditions on the form of magnesium stearate prepared by aqueous precipitation was examined. None of the preparation variables had any apparent effect on the crystal habit of magnesium stearate; however, the preparation conditions did affect the amount of moisture associated with the crystals. Heating the magnesium stearate at 105° C not only resulted in a loss of water of hydration from the crystals, but also a disruption of the crystals' 3-dimensional lattice structure. Both of these effects could be reversed by storing the dried crystals under appropriate relative humidity conditions.