H. C. Beyerman, J. Hirt, P. Kranenburg
Feb 4, 1975
Citations
0
Influential Citations
15
Citations
Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
The coupling of histidine derivatives by the excess mixed anhydride method was investigated with respect to the yield, the racemization, and the formation of by-products. The tert-butyloxycarbonyl- (Boc-), isobutyloxycarbonyl- (i-Boc-), benzyloxycarbonyl- (Z-), and p-toluenesulfonyl-(Tos-) groups were found to be suitable for protection of the imidazole nucleus. A new way of selective removal of the Nim-Tos group, with pyridine hydrochloride, is described.