Jiangli Zhang
2005
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Journal
Journal of Lanzhou College of Petrochemical Technology
Abstract
4-phenyl-2-butanone is a important medium to synthesize medicine for diminish inflammation and codeine.The ethyl ethanate is synthesized with ethanol and acetic acid as materials and strong acid as catalyst(such as sulfuric acid,chloric acid,p-methyl-benzene sulfonic acid and strong acidity ion exchange resin etc.).Ethyl acetoacetate ia compounded by Claisen's condensation with a series of acid,alkali,nucleophilic addition and remove reaction.And the synthesis of 4-phenyl-3-methyl ethanate-2-butanone is by ethyl acetoacetate with benzyl chloride via substitution reaction.4-phenyl-2-butanone via 4-phenyl-3-methyl ethanate-2-butanone hydrolysis to decarboxylize.