Rong Gu, A. Hameurlaine, W. Dehaen
2006
Citations
0
Influential Citations
4
Citations
Journal
Synlett
Abstract
The synthesis of novel 6-monosubstituted 5,11-dihydroindolo[3,2-b]carbazoles was accomplished by a three-stage one-pot procedure involving condensation of indole and an aldehyde affording 3,3′-bis(indolyl)methanes, followed by isomerization to the 2,3′-analogues and acid-catalyzed intramolecular reaction with triethyl orthoformate to give the corresponding 6-monosubstituted indolo[3,2-b]carbazoles in good overall yield. Different substitution patterns, such as N-alkylation, N-arylation, formylation and bromination, were successfully introduced, leading to the formation of novel substituted 5,11-dihydroindolo[3,2-b]carbazole derivatives.