T. Kuroda, F. Suzuki
May 1, 1993
Citations
0
Influential Citations
2
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A convenient synthesis of a new heterocycle, 5,6,7,8-tetrahydropyrido[2,1-b]purin-10-one 1 was described. 4-Amino-N-(5-chloropentanoyl)-5-imidazolecarboxamide 3a was successively cyclized to 1 with polyphosphoric acid at 150 o . Methylation of 1 under basic condition proceeded selectively at N-1 to afford 6 as the sole product