Peter Šilhár, R. Pohl, I. Votruba
Aug 20, 2004
Citations
0
Influential Citations
37
Citations
Journal
Organic letters
Abstract
[reaction: see text] A facile and efficient methodology of the synthesis of 6-(hydroxymethyl)purine derivatives (bases and nucleosides) was developed based on Pd-catalyzed cross-coupling reactions of 6-halopurines with acyloxymethylzinc iodides followed by deprotection. Several title compounds are inhibitors of adenosine deaminase and exert cytostatic activity.