Facile and green synthesis of 4,6-dimethoxy-2-methylsulfonylpyrimidine using chloromethane as methylating agent

doi:10.1080/02533839.2020.1839356

Paper

Facile and green synthesis of 4,6-dimethoxy-2-methylsulfonylpyrimidine using chloromethane as methylating agent

Published Nov 11, 2020 · Jing Guan, Hang Hu, Bin Wang

Journal of the Chinese Institute of Engineers

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Abstract

ABSTRACT 4,6-dimethoxy-2-methylsulfonylpyrimidine (DMSP) is an important chemical intermediate which has been widely used in the synthesis of plant growth regulators, pesticides, and fungicides. However, the traditional synthetic manufacturing process involves highly toxic dimethylsulfate and highly corrosive phosphorus oxychloride, causing serious environmental problems. To overcome these problems, we utilized chloromethane instead of dimethylsulfate as a methylating agent to synthesize DMSP. The reaction was shortened to only2 steps. Since 4,6-dimethoxy-2-methylthiopyrimidine is the key intermediate in the synthesis of DMSP, it is of great importance to improve the conversion and selectivity. In this work, 4,6-dimethoxy-2-methylthiopyrimidine was synthesized from 2-thiobarbituric acid in the presence of potassium carbonate and chloromethane through a one-step procedure. By optimization of reaction conditions, high conversion of 2-thiobarbituric acid (85.7%) and selectivity of 4,6-dimethoxy-2-methyl thiopyrimidine (53.1%) were obtained. Compared to the traditional synthetic pathway, our new synthetic process is more economical and environment-friendly.

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Our new green synthetic process for 4,6-dimethoxy-2-methylsulfonylpyrimidine (DMSP) using chloromethane as a methylating agent achieves high conversion and selectivity, making it more economical and environmentally friendly than traditional methods.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Facile and green synthesis of 4,6-dimethoxy-2-methylsulfonylpyrimidine using chloromethane as methylating agent

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References

Phosphoacetylcholinesterase: toxicity of phosphorus oxychloride to mammals and insects that can be attributed to selective phosphorylation of acetylcholinesterase by phosphorodichloridic acid.

Phosphorus oxychloride's acute toxicity is due to its hydrolytic activation to phosphorodichloridic acid, which selectively phosphorylates acetylcholinesterase at the active site, causing enzymatic inactivation.

Phosphorus trichloride toxicity. Preliminary report.

Phosphorus trichloride toxicity caused acute respiratory effects in some individuals exposed to a railroad accident, with some showing improvement one month later.

Developmental toxicity of dimethyl sulfate by inhalation in the rat.

Dimethyl sulfate (DMS) is not a developmental toxin in rats when exposed to up to 1.5 ppm during major organogenesis, with no clinical signs or fetal effects observed.

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