Q. Su, Jianwei Guo, Chufen Yang
Oct 1, 2011
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Journal
Applied Mechanics and Materials
Abstract
A facile method for the synthesis of N-{2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl} adamantane-1-carboxamide(Adatanserin) was developed by using 2-chloropyrimidine and adamantanecarbonyl chloride as the starting material via amidation and N-alkylation, using convergent route to reduce workups and steps in a good yield. The structures of compounds were confirmed by IR spectral, 1HNMR and elemental analyses.