The fate of acetanilide in man.

doi:10.1016/s0022-3565(25)03462-7

Paper

The fate of acetanilide in man.

Published Sep 1, 1948 · B. Brodie, J. Axelrod

The Journal of pharmacology and experimental therapeutics

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161

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2

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

Acetanilide's analgesic action is mainly mediated through N-acetyl p-aminophenol, which is oxidized in the liver and excreted in a conjugated form.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The fate of acetanilide in man.

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References

Citations

Analysis of friction ridge evidence for trace amounts of paracetamol in various pharmaceutical industries by Raman spectroscopy

This study successfully identified paracetamol in fingerprints using Raman spectroscopy, providing a noninvasive forensic trace detection method for drugs containing 500 mg of paracetamol.

Acetaminophen-Induced Hepatic Necrosis: A Reminiscence.

Acetaminophen-induced liver necrosis in rats was discovered in the early 1970s, leading to antidotal therapy for acetaminophen overdose patients.

Paracetamol (acetaminophen) poisoning: The early years

Paracetamol overdose treatment has improved over the years, but liver transplantation remains the only effective treatment for late-presenting patients.

Transcriptomic Analysis of Acetaminophen Biodegradation by Penicillium chrysogenum var. halophenolicum and Insights into Energy and Stress Response Pathways

The fungus Penicillium chrysogenum var. halophenolicum can metabolize acetaminophen through a complex pathway, generating nontoxic metabolites, showing potential for bioremediation of this drug.

White Rot Fungi Produce Novel Tire Wear Compound Metabolites and Reveal Underappreciated Amino Acid Conjugation Pathways

White rot fungi effectively remove 81.9% of acetanilide and 69.6% of HMMM from stormwater, highlighting the importance of amino acid conjugation in biotransformation of contaminants.