D. Yohannes, C. P. Hansen, S. Akireddy
Nov 13, 2008
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0
Influential Citations
9
Citations
Journal
Organic letters
Abstract
The first total synthesis of the natural product 3-hydroxy-11-norcytisine (1), structurally related to cytisine (2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.