Avi Weissberg, B. Halak, M. Portnoy
May 3, 2005
Citations
0
Influential Citations
33
Citations
Journal
The Journal of organic chemistry
Abstract
Chiral Pybox (pyridine-2,6-bis(oxazoline)) ligands can be cleanly and efficiently prepared on polystyrene support via a five-step solid-phase synthetic sequence. Cu(I)-complexed polymer-bound Pybox was used as a catalyst in the first heterogeneously catalyzed asymmetric addition of alkynes to imines. Best enantioselectivity was observed with (t)Bu-substituted oxazolines.