K. Curtis, J. Fawcett, S. Handa
Aug 8, 2005
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The novel (2 S ,3 S ,4 R )-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine 5 has been produced in an efficient synthesis from trans -4-hydroxy- l -proline 8 . The key step involves a tethered aminohydroxylation of the alkene 7 to introduce regio- and stereoselectively the amino alcohol functionality in the resulting products 6 and 13 . Subsequent deprotection steps furnish the target molecule 5 as well as several differentially protected analogues.