First Synthesis of Methyl 2-Amino-6-Methoxynicotinate Using a Combination of Microwave and Flow Reaction Technologies

doi:10.1055/S-0030-1259283

Paper

First Synthesis of Methyl 2-Amino-6-Methoxynicotinate Using a Combination of Microwave and Flow Reaction Technologies

Published 2011 · György Jeges, Tamas Meszaros, T. Szommer

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Abstract

The synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for the preparation of fused 2-pyridones, is reported. The optimized synthesis includes sequential microwave-induced regioselective 6-methoxylation, esterification, followed by microwave-induced reaction with p-methoxybenzylamine, and final deprotection under flow reaction hydrogenation conditions. Two key steps in the reported synthesis are a microwave-induced methoxylation and a microfluidic hydrogenation that afford improved regioselectivity and purity profile of the reaction products.

Study Snapshot

Microwave-induced methoxylation and microfluidic hydrogenation improve regioselectivity and purity in the synthesis of methyl 2-amino-6-methoxynicotinate, a valuable building block for fused 2-pyridones.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

First Synthesis of Methyl 2-Amino-6-Methoxynicotinate Using a Combination of Microwave and Flow Reaction Technologies

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References

Citations

Highlights from the Flow Chemistry Literature 2011 (Part 2)

This paper highlights key publications in continuous flow chemistry, with graphical abstracts, and presents the remaining publications in the field, grouped by journal name and review articles.