Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats.

doi:10.1002/mnfr.201500761

Paper

Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats.

Published Feb 23, 2016 · I. Najmanová, J. Pourová, M. Vopršálová

Molecular nutrition & food research

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76

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Abstract

There are reports of positive effects of quercetin on cardiovascular pathologies, however, mainly due to its low biovailability, the mechanism remains elusive. Here, we report that one metabolite formed by human microflora (3-(3-hydroxyphenyl)propionic acid)relaxed isolated rat aorta and decreased arterial blood pressure in rats.

Non-RCT

Animal Study

Rigorous Journal

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Study Snapshot

Human microflora's 3-(3-hydroxyphenyl)propionic acid metabolite relaxes rat aorta and decreases arterial blood pressure, suggesting potential benefits for cardiovascular health.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats.

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