Jianguo Xu, Jiangang Yu, Yi Jin
Nov 1, 2017
Citations
0
Influential Citations
18
Citations
Journal
Chemical Engineering and Processing
Abstract
Abstract A new procedure of microwave-assisted organic synthesis in flow was designed and introduced for Fischer indole synthesis of 7-ethyltryptophol (7-ET). By using back-pressure regulator (BPR), a reaction temperature of 180 °C could be easily and readily achieved even in a low-boiling solvent [water/ethylene glycol(EG)]. At this temperature, the synthesis of 7-ET from 2-ethylphenylhydrazine and 4-hydroxybutanal in flow was successful (78% net yield) and practical (short residence time: 30 s) with a simple purification process of extraction.