B. Solomon, R. Collins, R. Sharma
Aug 1, 1997
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0
Influential Citations
70
Citations
Quality indicators
Journal
Journal of the American Academy of Dermatology
Abstract
Fluconazole, a water soluble bis-triazole, is a highly selective inhibitor of fungal cytochrome P450 and sterol 14-alpha demethylation. It has good bioavailability, low protein binding, and a long half-life. After oral administration it rapidly distributes to the subcutaneous tissues and epidermis, where it accumulates. Favorable results have been obtained with fluconazole in the treatment of various systemic mycoses, candidiasis, and dermatophyte infections. We studied the efficacy of fluconazole in the treatment of tinea capitis in children.