K. Sivanandaiah, V. Sureshbabu, B. P. Gangadhar
1994
Citations
0
Influential Citations
1
Citations
Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
9-Fluorenylmethoxycarbonyl (Fmoc) amino acid chlorides can be used along with 1-hydroxybenzotriazole potassium salt (KOBt) instead of the routinely employed 1:1 mixt. of base [Et3N or EtN(CHMe2)2] and catalyst [1-hydroxybenzotriazole (HOBt) or pivalic acid] in solid phase peptide synthesis. No addnl. base is required. Coupling is fast and racemization free. Thus, the opioid peptide β-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) and the laminin fragment H-Tyr-Ile-Gly-Ser-Arg-NH2 have been obtained in good yields as well as purity.