Fragmentation of diamide derivatives of 3,4-ethylenedioxythiophene.

doi:10.1002/rcm.6196

Paper

Fragmentation of diamide derivatives of 3,4-ethylenedioxythiophene.

Published May 15, 2012 · I. Stolić, I. Bratoš, G. Kovačević

Rapid communications in mass spectrometry : RCM

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Abstract

The sequential product ion (MS(n)) fragmentation of four symmetric diamide derivatives of 3,4-ethylenedioxythiophene were characterized using ion trap mass spectrometry with electrospray ionization and their fragmentation patterns were studied. The experimental data consists of mass spectra obtained by tandem mass spectrometry, and calculations were obtained by the M06-2X/6-31 G (d,p) method. Investigated compounds represent building blocks in synthesis of compounds used in different areas of chemistry and industry such as in medicinal chemistry, as potential anticancer and anticonvulsant agents, in organic chemistry as linkers for solid-phase synthesis, and in the synthesis of a variety of materials in polymer chemistry. We present herein the investigation of the fragmentation pathway of protonated diamide derivatives of 3,4-ethylenedioxythiophene that involves the identification of fragments, influence of proton transfer on direction of fragmentation and mechanisms of reactions by which the fragmentation process occurs. Data obtained from product ion spectra of these protonated compounds and density functional theory (DFT) calculations indicate that the fragmentation process takes place via four main reactions: amido-iminol proton transfer, reverse cycloaddition, cleavage of the amide bond, and isocyanic acid elimination. The 3,4-ethylenedioxythiophene-2,5-dicarboxamide was observed as an intermediate in the fragmentation of its alkyl derivatives. To our knowledge, this work brings the first correct description of the mechanism of elimination of isocyanic acid.

Study Snapshot

The fragmentation of diamide derivatives of 3,4-ethylenedioxythiophene occurs via four main reactions: amido-iminol proton transfer, reverse cycloaddition, cleavage of the amide bond, and isocyanic acid elimination.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Fragmentation of diamide derivatives of 3,4-ethylenedioxythiophene.

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References

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Citations

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This study developed a semipreparative liquid chromatographic method to isolate 5-methylpyranopelargonidin and 4-methylfuropelargonidin from pelargonidin in methanol, acetone, and aqueous hydrochloric acid, and found them in strawberry fruit wine

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Diphenylfuran diamidines show potential as antitumor agents due to their unique fragmentation patterns and stability.