H. Ucar, K. V. Derpoorten, P. Depovere
Feb 26, 1998
Citations
1
Influential Citations
15
Citations
Journal
Tetrahedron
Abstract
6-Acyl-2(3H)-benzoxazolone and 6-acyl-2(3H)-benzothiazolone derivatives have particularly interesting anti-inflammatory, antiepileptic, analgesic and antiviral properties. in this study, we report an original method of acylation on the 6-position of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone which consists in a two-step procedure involving migration of the acyl group from the N-position to the 6-position of the heterocycle, at 165 degrees C and catalyzed by AlCl3. This new procedure was found to be more efficient with regard to the consumption of AlCl3 and the yield (76-90%) than other acylation methods previously described. (C) 1998 Elsevier Science Ltd. All rights reserved.