J. R. Denton, Scott M. Thomas, B. Mao
Nov 10, 2015
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Influential Citations
2
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Journal
Journal of pharmaceutical and biomedical analysis
Abstract
2-Hydroxypyridine-1-oxide (HOPO) is utilized in the pharmaceutical sector to facilitate the formation of amide bonds. This present work describes the development of a HPLC high pH ion-pairing method for the trace analysis of HOPO in pharmaceutically relevant materials. Several method development aspects are discussed and the application of this method to several late-stage programs is presented.