Olle Heby, Lo Persson
Apr 1, 1990
Citations
17
Influential Citations
475
Citations
Quality indicators
Journal
Trends in biochemical sciences
Abstract
The polyamines putrescine, spermidine and spermine are important cellular constituents involved in the regulation of cell growth and differentiation. Their intracellular levels are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and excretion. As a result of the application of molecular biology techniques, some of these mechanisms are presently being unravelled, and are providing a basis for the rational development of novel agents effective against proliferative disorders and various parasitic diseases.