Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.

doi:10.1016/J.BBRC.2003.09.085

Paper

Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.

Published Oct 24, 2003 · Y. Shimizu, N. Nagaya, Y. Teranishi

Biochemical and biophysical research communications

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134

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4

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Abstract

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Study Snapshot

Ghrelin improves endothelial dysfunction and increases nitric oxide synthase expression in rats through growth hormone-independent mechanisms.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.

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References

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

Ghrelin and des-acyl ghrelin may act as survival factors for the cardiovascular system through binding to a novel receptor distinct from GHSR-1a, potentially preventing cell death in cardiomyocytes and endothelial cells.

Central Ghrelin Modulates Sympathetic Activity in Conscious Rabbits

Intravenous ghrelin decreases arterial pressure and renal sympathetic nerve activity in conscious rabbits, while central ghrelin participates in regulating sympathetic nerve activity to the kidney and the baroreceptor reflex.

Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin‐1

Ghrelin is a potent endothelium-independent vasodilator of endothelin-1 in human arteries, producing responses similar to those of adrenomedullin.

Vasodilatory Effect of Ghrelin, an Endogenous Peptide From the Stomach

Ghrelin has vasodilatory effects through growth hormone/IGF-I/nitric oxide-independent mechanisms, suggesting it may have a role in regulating blood flow.

Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

Chronic subcutaneous administration of ghrelin improves left ventricular dysfunction and reduces cardiac cachexia in rats with chronic heart failure.

Citations