Yan Zhang, Xiaomei Yang, ShuangSheng Wang
Aug 18, 2019
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Journal of agricultural and food chemistry
Abstract
Ginseng, the roots and rhizomes of Panax ginseng C. A Meyer, is not only used as herbal medicine but also used as functional food to support body functions. Ginsenoside Rg3 (GRg3) is a major bioactive component in ginseng. In this study, the beneficial effects of GRg3 on Alzheimer's disease (AD) rats were evaluated via the behavioral experiment and anti-oxidant capacity. Moreover, metabolomic analysis based on UPLC-QTOF-MS/MS and apoptosis analysis were used to obtain the change between AD and GRg3-administrated rats to assess the underlying mechanisms on improving mitochondrial dysfunction. Results showed that GRg3 could prevent cognitive impairment of AD rats by improving the mitochondrial dysfunction. The potential mechanisms were related to regulate abnormality of energy metabolism, electron transport chain, amino acid metabolism, purine metabolism, and anti-apoptosis. These findings support the exploitation of GRg3 as an effective complementary and functional food to prevent and delay AD.