I. Makarevich, S. G. Kislichenko, D. G. Kolesnikov
2004
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Journal
Chemistry of Natural Compounds
Abstract
SummaryThree cardiac glycosides have been synthesized from gitoxigenin and D-glucose: gitoxigenin 3β-O-β-D-glucopyranoside, gitoxigenin 16β -O-β -D-glucopyranoside, and gitoxigenin 3β, 16β-di-O-β -D-glucoside. The first glycoside, obtained with a yield of 49% on the weight of the initial aglycone, possesses a fairly high biological activity (0.25 mg/kg), while the other two, formed in a yield of about 0.3%, do not possess the action on the heart that is specific for the cardenolides.