Glucosamine Enhances Tissue Regeneration In The Process Of Wound Healing In Rats As Animal Model; A Stereological Study

doi:10.4172/2157-7099.1000150

Paper

Glucosamine Enhances Tissue Regeneration In The Process Of Wound Healing In Rats As Animal Model; A Stereological Study

Published Jul 18, 2012 · S. Ashkani-Esfahani, Yasaman Emami, E. Esmaeilzadeh

Journal of Cytology and Histology

UNKNOWN SJR score

22

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0

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Abstract

Introduction: Glucosamine (GA), a water soluble hexosamine made from chitin or chitosan, was showed to have stimulatory effect on matrix formation, enhancing inflammatory response, modulating hyaluronic acid synthesis which promotes extracellular matrix remodeling leading to better wound healing. GA was also shown to have antioxidant and immunomodulatory effect which play roles in wound healing process. In this study we aimed to determine the effect of topical administration of GA on wound healing process in rats as animal model. Material and methods: 36 Wistar rats were divided into 3 groups; the control group which received no treatment; the Glucosamine group that received GA gel with 2% GA concentration, and the Base group that was treated with the vehicle. A 1 cm full-thickness wound was created on the posterior of each rat’s neck. Treatments took place every 24 hours for 15 days. The wound closure rate, volume density of collagen bundles and vessels, fibroblast population, length density and mean diameter of the vessels were estimated by using unbiased stereological and histomorphometrical methods. Results: GA enhanced the wound closure rate consequently as well as fibroblast proliferation, collagen synthesis and proliferation of hair follicles in contrast with the base and the control group. Although not statistically significant, GA also improved the revascularization process in the wound site. Conclusion: Results of this study indicate that GA has the potential for being used for treatment of skin wounds; however, still further evaluations on its mechanisms of action and clinical advantages and disadvantages should be performed.

RCT

Animal Study

Study Snapshot

Topical glucosamine gel enhances wound healing in rats by promoting tissue regeneration and promoting wound closure, but further evaluations are needed.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Glucosamine Enhances Tissue Regeneration In The Process Of Wound Healing In Rats As Animal Model; A Stereological Study

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References

The Healing Effect of Arnebia Euchroma in Second Degree Burn Wounds in Rat as an Animal Model

Arnebia euchroma herbal extract is an effective treatment for second degree burn wounds, with similar healing effects to silver sulfadiazine, but with fewer side effects.

N-Acetylglucosamine suppress collagenases activation in ultraviolet B-irradiated human dermal fibroblasts: Involvement of calcium ions and mitogen-activated protein kinases.

GlcNAc protects human skin fibroblasts from UVB damage by inhibiting collagenase activation and regulating calcium-dependent signaling pathways, potentially aiding in skin photoaging prevention and treatment.

Glucosamine Improved Atopic Dermatitis‐like Skin Lesions in NC/Nga Mice by Inhibition of Th2 Cell Development

Glucosamine effectively reduces atopic dermatitis-like skin lesions in mice by inhibiting Th2 cell development, suggesting it may be a useful immunomodulatory agent for treating human atopic dermatitis.

Recent aspects of the anti-inflammatory actions of glucosamine

Glucosamine acts as both a chondroprotective agent and an anti-inflammatory molecule in the body, reducing inflammation in various diseases.

Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride.

Glucosamine-hydrochloride (GS-HCl) differentially down-regulates COX-2 and MMP-13 expression in human skin fibroblasts, potentially reducing inflammation and promoting healing.

Citations

Multibiofunctional Self-healing Adhesive Injectable Nanocomposite Polysaccharide Hydrogel.

The F-CuO nanosheet cross-linked injectable hydrogel composite demonstrates fast self-healing, excellent antibacterial properties, and cytocompatibility, making it a promising candidate biomaterial for addressing clinical challenges.

A review of the current state of natural biomaterials in wound healing applications

Natural biomaterials, combined with synthetic biomaterials and bioactive agents, can enhance wound healing and prevent infection, but require further research for optimal properties and extraction methods.

Chitosan/Gelatin Scaffolds Loaded with Jatropha mollissima Extract as Potential Skin Tissue Engineering Materials

Chitosan/gelatin scaffolds loaded with Jatropha mollissima extract show potential as skin tissue engineering materials due to their biodegradation and biocompatibility with L929 cells.

Multifaceted production strategies and applications of glucosamine: a comprehensive review

Glucosamine production methods, including genetic engineering of Escherichia coli and Bacillus subtilis, have improved the quality and yield of this essential amino acid for various applications.

Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite

Nano-chitosan and its nano-copper composite show high antimicrobial activity and hematological activity, with potential applications in blood treatment.

Investigation of the Antimicrobial Activity and Hematological Pattern of Nano-Chitosan and its Developed Nano-Copper Composite

The synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) shows high antimicrobial activity and hematological activity, with potential applications in blood treatment.

Computational Assessment of the Pharmacological Profiles of Degradation Products of Chitosan

Chitosan degradation products show promising pharmacological profiles and limited toxicological effects on humans, with potential inhibition of organic anion transporting peptides and weak cardiotoxicity.

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

GlcNAc-loaded chitosan filaments show promise as biodegradable and biocompatible absorbable suture materials, potentially enhancing healing processes, relieving pain, and minimizing infection at the surgery site.

In Vivo Assay of Wound Healing Activities of Silymarin Extract on Cutaneous Wounds Caused by Leishmania major

Silymarin extract at both 5% and 10% concentrations accelerates wound closure and improves collagen synthesis and revascularization in Leishmania major-induced skin wounds.