W. Mi
2015
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Journal
Fine Chemical Intermediates
Abstract
To review the existing synthetic routes of vandetanib was summarized, and different synthetic routes were analyzed to find a suitable industrial production of synthetic routes. By analyzing and summarizing these synthetic route discovery that tert-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate(6) and ethyl vanillate(22)were subjected to substitution, deprotection, methylation, nitration, reduction, cyclization, chlorination, substitution to give the title compound(1). It showed more favorable, yield higher and commercial value in the manufacturing scale.