Margherita Guasconi, Xiaoyun Lu, A. Massarotti
May 18, 2011
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Influential Citations
14
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Journal
Organic & biomolecular chemistry
Abstract
In a program aimed at discovering novel protein kinase inhibitors, a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines has been developed exploiting the isocyanide-based multicomponent Blackburn reaction, followed by a nucleophilic aromatic substitution with ammonia or primary and secondary amines. The potential of the reported scaffold is strengthened by the inhibition of STAT5-dependent transcription displayed by four of the synthesized compounds.