Feb 7, 2020
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T he hydrochloride salt form of guanfacine, a centrally acting alpha-2 adrenergic agonist with antihypertensive activity. Alpha-2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. T his leads to a decrease in heart rate and peripheral vascular resistance. (NCI05) Qeios · Definition, February 7, 2020