Ma Li
1991
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Chinese Journal of Pharmacology and Toxicology
Abstract
Hernandezine, an isoquinoline alkaloid, is one of the active ingredients isolated from Thalictrum glandulosissimum. It was found to inhibit markedly rat platelet aggregation induced by collagen, ADP, calicimycin (A-23187) and arachidonic acid (AA) in vitro. The IC50 were 14.5, 41.6, 44.1 and 48.3μg/ml, respectively. Hernandezine (25, 50 and 100 μg / ml) could not inhibit the formation of MDA in-duced by AA. Hernandezine could increase the concentration of cAMP in rabbit platelet and inhibit the increase of the cytosolic free Ca2+ concentration in human platelet induced by thrombin.