V. Tolman, J. Hanuš, P. Sedmera
1999
Citations
1
Influential Citations
11
Citations
Journal
Collection of Czechoslovak Chemical Communications
Abstract
( Z )-6-(4-Hydroxy-3-methylbut-2-en-1-ylamino)purine, ( Z )-zeatin, and the isomeric ( Z )-isozeatin, both free from the E isomers, were prepared using the cycloaddition of the in situ generated tert -butyl nitrosoformate on isoprene. A mixture of tert -butyl 5(and 4)-methyl-3,6-dihydro-2 H -1,2-oxazine-2-carboxylates thus formed was deprotected and reductively cleaved to ( Z )-4-amino-2(and 3)-methylbut-2-en-1-ols, which were chromatographically separated and finally alkylated with 6-chloropurine to give the title compounds.