Esra’a S. Abu-Sheaib, Jalal A. Zahra, M. El-Abadelah
May 1, 2008
Citations
0
Influential Citations
8
Citations
Journal
Zeitschrift für Naturforschung B
Abstract
Cyclocondensation reaction of ethyl 7,8-diamino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline- 3-carboxylate (2) or the -3-carboxylic acid 3 with sym-1,2- diketones produced the corresponding ethyl 2,3-disubstituted pyrido[2,3- f ]quinoxaline-8-carboxylates (4a - h) or the -8-carboxylic acids 5a - h, respectively. The structures for these new heterocycles are supported by analytical and spectral (IR, MS, NMR) data. Compounds 5a - c, g, h exhibit moderate activity against an assortment of bacterial species.