A. S. Ramos, Joyce Benzaquem Ribeiro, Raquel de Oliveira Lopes
Nov 16, 2011
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Seven wild-type microorganism strains were used to reduce ethyl 3-oxohexanoate to ethyl ( R )-3-hydroxyhexanoate. Free cells of Kluyveromyces marxianus and Aspergillus niger led to higher than 99% of conversion with higher than 99% ee. After immobilization in calcium alginate spheres, cells of K. marxianus exhibited high enantioselectivity (>99% ee) and conversion level (99%) within 24 h even if substrate was added at concentration of 10 g/L (62 mM).