T. Ushio, Keiji. Yamamoto
Nov 4, 1994
Citations
0
Influential Citations
15
Citations
Journal
Journal of Chromatography A
Abstract
Abstract A high-performance liquid Chromatographic method for the direct chiral resolution of suplatast tosilate (ST), {2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl}dimethylsulfonium p-toluenesulfonate and its decomposed products was developed using a cellulose tris-3,5-dimethylphenylcarbamate (Chiralcel OD-H) column eluted with a mixture of n-hexane, ethanol, trifluoroacetic acid and diethylarnine. The method was applied to determination of the enantiomeric excess and chiral resolution of decomposed products of ST. The enantiomeric purity of the alternatively synthesized enantiomers was estimated to be 98.6% and 99.7% (enantiomeric excess) for (+)- and (−)-ST, respectively. No racemization of ST enantiomer was observed with decomposition at pH 6.8 and 37°C.