S. Masur, E. Holtzman, R. Walter
Jan 1, 1972
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Journal
The Journal of Cell Biology
Abstract
It is well established that neurohypophyseal observations (40) of çontinuity between the hormones and cyclic 3',5'-adenosine monogranule membrane and the plasma membrane . phosphate (cAMP) increase the permeability The present findings indicate that the frequency of the amphibian bladder to water and enhance of such membrane continuities is greatly increased the transport of sodium across the mucosal in cells stimulated by oxytocin or the dibutyryl epithelium (16, 17, 27) . Recently, we reported derivative of cAMP as compared to unstimulated that in the toad bladder mucosal epithelium, the controls . altered permeability is paralleled by a marked increase in the endocytic uptake of horseradish MATERIALS AND METHODS peroxidase from the lumen (31-33) . One of the The following compounds were used in this study : possible explanations was that the observed oxytocin, prepared by Miss P. L. Hoffman at Mt . endocytosis might be a secondary effect . The Sinai School of Medicine by the solid-phase method primary effect in the response to hormone and of peptide synthesis (35) . The hormone was found cyclic nucleotide might conceivably be a stimuto possess an activity of 500 units/mg when tested in lation of exocytosis, the fusion of membranes the fowl vasodepressor assay just before use . N 6 -2'surrounding secretion granules with the plasma O-dibutyryl adenosine 3',5'-cyclic monophosphate membrane. This would result in the addition of (dibut . cAMP) was purchased from Schwarz Bio