K. Nakano, R. Tanaka, K. Nozaki
Aug 1, 2006
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0
Influential Citations
13
Citations
Journal
Helvetica Chimica Acta
Abstract
The asymmetric hydroformylation of 2- and 3-vinylfurans (2a and 2b, resp.) was investigated by using [Rh{(R,S)-binaphos}] complexes as catalysts ((R,S)-binaphos = (11bS)-4-{[1R)-2′-phosphino[1,1′-binaphthalen]-2-yl]oxy}dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin; 1). Hydroformylation of 2 gave isoaldehydes 3 in high regio- and enantioselectivities (Scheme 2 and Table). Reduction of the aldehydes 3 with NaBH4 successfully afforded the corresponding alcohols 5 without loss of enantiomeric purity (Scheme 3).